Romanian Journal of Information Science and Technology (ROMJIST)

An open – access publication

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ROMJIST is a publication of Romanian Academy,
Section for Information Science and Technology

Editor – in – Chief:
Radu-Emil Precup

Honorary Co-Editors-in-Chief:
Horia-Nicolai Teodorescu
Gheorghe Stefan

Secretariate (office):
Adriana Apostol
Adress for correspondence: romjist@nano-link.net (after 1st of January, 2019)

Founding Editor-in-Chief
(until 10th of February, 2021):
Dan Dascalu

Editing of the printed version: Mihaela Marian (Publishing House of the Romanian Academy, Bucharest)

Technical editor
of the on-line version:
Lucian Milea (University POLITEHNICA of Bucharest)

Sponsor:
• National Institute for R & D
in Microtechnologies
(IMT Bucharest), www.imt.ro

ROMJIST Volume 22, No. 2, 2019, pp. 135-143
 

C. Moldovan, A. Barbilian, G. Stergios, M. Drignei, E. Jovenet, I. Lascar, A. Berami, E. Drignei, L. Dobrescu, O. Dontu, D. Dobrescu, D. Besnea, B. Fartat, D. Dragomir, P.L. Milea, D. Muraru, T.P. Neagu, E.L. Stanciulescu, R. Scarlet, F. Sandru et al.
Design and fabrication of tubes-guided structure with electrical stimulation module for neural regeneration and in-vivo testing

ABSTRACT: The research work is proposing a new biointerface to permit functional recovering of peripheral nervous fascicles using repair surgery. One biointerface has been experimentally used for Lewis rats’ sciatic nerve. Simple tubes-guide structures are already experimentally used to safely regenerate peripheral nerves in recent years. Using dedicated software, the main tubular structure has been designed and then it has been 3D printed. Two types of gold electrodes (2 mm and 4 mm long) wrap the tube-guided structure in order to allow electric signals application around the tubes-guided structure. A special compact Wi-Fi electronic module containing a low frequency oscillator is attached to this structure. This novel biointerface enables a programmable electric stimulation process that accelerates the nerves growth after repair surgery. Functional tests were performed and their results show that the regeneration rate of the sciatic nerve of the rats increases. The implantation protocol has been designed and approved.

KEYWORDS: Electrical stimulation, nanoelectrodes, biointerface, peripheral nervous fascicles, tubes-guided

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